| Reseach project in the scope of the ARIS Call for Proposals for (co)funding of projects and programmes to enhance the international mobility of Slovenian researchers and research organisations and to promote the international engagement of Slovenian applicants (2024-2026) |
| Head: | Assist. Prof. Lea Rems, University of Ljubljana, Faculty of Electrical Engineering |
| Partner: | / |
| Funding: | European Union – NextGenerationEU, Ministry of Higher Education, Research and Innovation of Republic of Slovenia, and ARIS – Slovenian Research and Innovation Agency |
| Code: | MN-0023 |
The project is funded by the European Union – NextGenerationEU in the scope of the Recovery and Resilience Plan.
- Member of University of Ljubljana
- Code
- MN-0023
- Project
- Reseach project in the scope of the ARIS Call for Proposals for (co)funding of projects and programmes to enhance the international mobility of Slovenian researchers and research organisations and to promote the international engagement of Slovenian applicants
- Period
- 1. 3. 2024 - 28. 2. 2026
- Amount of financing
- 106.992,00 EUR
- Head
- Research activity
- PE7 - Systems and Communication Engineering
- Research Organisation
- Abstract
The project continues and extends the research initiated within the MSCA-IF project ” Controlling the susceptibility of biological cells to pulsed electric field treatment by using ion channel modulators – EPmIC”. The project investigates how the exposure of biological cells to intense pulsed electric field, which triggers the electroporation phenomenon, affects cellular electrophysiology, survival and gene transfection and how the response of cells after electroporation can be influenced by ion channel modulators. In our research, we use in vitro experimental models of nonexcitable cells (cell lines derived from healthy and tumor tissue) and excitable cells (genetically engineered excitable cell line S-HEK and primary cardiomyocytes). In addition, we are developing theoretical models for computer simulations to deepen our understanding of the mechanisms by which electroporation influences the cell response. This basic research makes an important contribution to the development of electroporation-based therapies such as tumor treatment, ablation of the heart muscle for treatment of cardiac arrhythmias, and gene therapy.
- Citations for bibliographic records
List of publications is available from our Publications page.