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Perfusion and oxygenation

By measuring various parameters of blood perfusion and oxygenation in tissues important information about physiology and pathology of the organism can be obtained. For this purpose we use different methods including near infrared spectroscopy (NIRS) for monitoring of tissue perfusion and blood oxygenation changes, laser Doppler flowmetry (LDF) for measurement of relative tissue microcirculation, and luminescence-based fiber-optic oximetry for measurement of oxygen partial pressure in tissue. These methods are based on different physical principles and measure parameters of perfusion and oxygenation on different physiological and anatomical levels. So far we have been using these and other methods for experimental diagnostic and therapeutic purposes in various studies on peripheral vascular disease, and skin/muscle and tumor blood flow and oxygenation.